In view of the advancement in the understanding about the most diverse types of cancer and
consequently a relentless search for a cure and increased survival rates of cancer patients …

Oncolytic viruses have been taking the front stage in biological therapy for cancer recently.
The first and most potent virus to be used in oncolytic virotherapy is human adenovirus …

Adenovirus vectors are the most commonly employed vector for cancer gene therapy. They
are also used for gene therapy and as vaccines to express foreign antigens. Adenovirus …

Objectives: Ablative therapies have been increasingly utilized in the treatment of locally
advanced pancreatic cancer (LAPC). Irreversible electroporation (IRE) is an energy delivery …

Nanotechnology refers to the interactions of cellular and molecular components and
engineered materials—typically, clusters of atoms, molecules, and molecular fragments into …

Pancreatic cancer is an aggressive disease that is predicted to become the second leading
cause of cancer-related death worldwide by 2030. The overall 5-year survival rate is around …

Abstract Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor
immunotherapy. However, potentially lethal toxicity associated with systemic administration …

Oncolytic viral therapy has been accepted as a standard immunotherapy since talimogene
laherparepvec (T-VEC, Imlygic®) was approved by the Food and Drug Administration (FDA) …

ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT
CNS Consortium conducted a dose-escalation trial of intracerebral injections of ONYX-015 …

Therapeutic oncolytic viruses (virotherapeutics) constitute a novel class of targeted
anticancer agents that have unique mechanisms of action compared with other cancer …