Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …

Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …

Understanding the genetic and epigenetic programs that control differentiation during
development is a fundamental challenge, with broad impacts across biology and medicine …

The immune system encodes information about the severity of a pathogenic threat in the
quantity and type of memory cells it forms. This encoding emerges from lymphocyte …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Natural and induced somatic mutations that accumulate in the genome during development
record the phylogenetic relationships of cells; whether these lineage barcodes capture the …

Clustering cells based on their high-dimensional profiles is an important data reduction
process by which researchers infer distinct cellular states. The advent of cellular barcoding …

Reconstructing the development of lineage relationships and cell fate mapping has been a
fundamental problem in biology. Using advanced molecular biology and single-cell RNA …

Simultaneous profiling of single-cell gene expression and lineage history holds enormous
potential for studying cellular decision-making. Recent computational approaches combine …

Computational biology is enabling an explosive growth in our understanding of stem cells
and our ability to use them for disease modeling, regenerative medicine, and drug …