It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Under physiological conditions, neurotransmitters shape neuronal networks and control
several cellular and synaptic functions. In the mammalian central nervous system (CNS) …

Acute hypoxic vasoconstriction and development of hypoxic pulmonary hypertension
(PHTN) are unique properties of the pulmonary circulation. The pulmonary endothelium …

A nitric oxide (NO)/cyclic GMP (cGMP) signaling pathway is thought to play an important role
in mammalian vasodilation during hypoxia. We show that Drosophila utilizes components of …

Nitric oxide (NO) is a potent vasodilator and inhibitor of vascular remodeling. Reduced NO
production has been implicated in the pathophysiology of pulmonary hypertension, with …

We hypothesized that cellular oxygen consumption is abnormal during sepsis as a result of
increased oxidative stress and selective mitochondrial damage. In a rat model of sepsis …

Red blood cell (RBC) transfusion is indicated to improve oxygen delivery to tissue, and for
no other purpose. We have come to appreciate that donor RBCs are fundamentally altered …

The mechanism by which hypoxia [low partial pressure of O2 (pO2)] elicits signaling to
regulate pulmonary arterial pressure is incompletely understood. We considered the …

The trapping, processing, and delivery of nitric oxide (NO) bioactivity by red blood cells
(RBCs) have emerged as a conserved mechanism through which regional blood flow is …

Vascular endothelial cells synthesize nitric oxide (NO) in response to agonists that elevate
cytosolic free Ca2+ concentrations. Once activated, NO synthase (NOS) requires arginine …