High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

The integrity of genomic DNA is continuously challenged by the presence of DNA base
lesions or DNA strand breaks. Here we report the identification of a new DNA damage …

Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …

This review deals with podocyte proteins that play a significant role in the structure and
function of the glomerular filter. Genetic linkage studies has identified several genes …

Objective This review aimed to summarize recent progress on syndromic dentin defects,
promoting a better understanding of systemic diseases with dentin malformations, the …

Helicases are enzymes that use ATP‐driven motor force to unwind double‐stranded DNA or
RNA. Recently, increasing evidence demonstrates that some helicases also possess …

Focal segmental glomerulosclerosis (FSGS) is not a disease, rather a pattern of histological
injury occurring from a variety of causes. The exact pathogenesis has yet to be fully …

SMARCAL1 catalyzes replication fork remodeling to maintain genome stability. It is recruited
to replication forks via an interaction with replication protein A (RPA), the major ssDNA …

Over the course of DNA replication, DNA lesions, transcriptional intermediates and protein-
DNA complexes can impair the progression of replication forks, thus resulting in replication …