Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …
[HTML][HTML] A systematic review on early prediction of Mild cognitive impairment to alzheimers using machine learning algorithms
KPM Niyas, P Thiyagarajan - International Journal of Intelligent Networks, 2023 - Elsevier
Background A person consults a doctor when he or she is suspicious of their cognitive
abilities. Finding patients who can be converted into Alzheimer's in the future is a difficult …
abilities. Finding patients who can be converted into Alzheimer's in the future is a difficult …
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Association of elevated amyloid and tau positron emission tomography signal with near-term development of Alzheimer disease symptoms in older adults without …
C Strikwerda-Brown, DA Hobbs, J Gonneaud… - JAMA …, 2022 - jamanetwork.com
Importance National Institute on Aging–Alzheimer's Association (NIA-AA) workgroups have
proposed biological research criteria intended to identify individuals with preclinical …
proposed biological research criteria intended to identify individuals with preclinical …
Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …
[HTML][HTML] Higher coffee consumption is associated with slower cognitive decline and less cerebral Aβ-amyloid accumulation over 126 months: data from the Australian …
SL Gardener, SR Rainey-Smith… - Frontiers in Aging …, 2021 - frontiersin.org
Background-Worldwide, coffee is one of the most popular beverages consumed. Several
studies have suggested a protective role of coffee, including reduced risk of Alzheimer's …
studies have suggested a protective role of coffee, including reduced risk of Alzheimer's …
Biomarkers for Alzheimer's disease: context of use, qualification, and roadmap for clinical implementation
J Cummings, J Kinney - Medicina, 2022 - mdpi.com
Background and Objectives: The US Food and Drug Administration (FDA) defines a
biomarker as a characteristic that is measured as an indicator of normal biological …
biomarker as a characteristic that is measured as an indicator of normal biological …
The future of precision medicine in the cure of Alzheimer's disease
This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …
Plasma glial fibrillary acidic protein is associated with 18F-SMBT-1 PET: two putative Astrocyte reactivity biomarkers for Alzheimer's disease
Background: Astrocyte reactivity is an early event along the Alzheimer's disease (AD)
continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity …
continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity …