[HTML][HTML] Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

DA Dumesic, DR Meldrum, MG Katz-Jaffe, RL Krisher… - Fertility and sterility, 2015 - Elsevier
Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

MG Da Broi, VSI Giorgi, F Wang, DL Keefe… - Journal of assisted …, 2018 - Springer
An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

Impact of oxidative stress on oocyte competence for in vitro embryo production programs

S Soto-Heras, MT Paramio - Research in Veterinary Science, 2020 - Elsevier
Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key
step for the success of the in vitro production (IVP) of embryos. One of the known disruptors …

The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo

J Castillo, M Jodar, R Oliva - Human reproduction update, 2018 - academic.oup.com
BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …

[HTML][HTML] Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

X Huang, B Wu, M Chen, L Hong, P Kong, Z Wei… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in
reproductive women and is characterized by polycystic ovaries, hyperandrogenism and …

Equilibrium between anti‐oxidants and reactive oxygen species: a requisite for oocyte development and maturation

M Kala, MV Shaikh, M Nivsarkar - Reproductive medicine and …, 2017 - Wiley Online Library
Reactive oxygen species (ROS) are required for cellular functioning and are controlled by
anti‐oxidants. The ROS influence the follicles, oocytes, endometrium, and their environment …

S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome

H Li, X Huang, X Chang, J Yao, Q He… - Journal of cellular …, 2020 - Wiley Online Library
Exosomes have recently emerged as key mediators of different physiological and
pathological processes. However, there has been few report about proteomic analysis of …

Proteomic analysis of human follicular fluid from fertile women

AM Zamah, ME Hassis, ME Albertolle, KE Williams - Clinical proteomics, 2015 - Springer
Background Follicular fluid is a unique biological fluid in which the critical events of oocyte
and follicular maturation and somatic cell-germ cell communication occur. Because of the …

Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development

AS Ambekar, DS Kelkar, SM Pinto… - The Journal of …, 2015 - academic.oup.com
Context: Polycystic ovary syndrome (PCOS), a major cause of anovulatory infertility, is
characterized by arrested follicular growth. Altered protein levels in the follicular fluid …