Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

The nervous system in the body is a complex network of nerves and cells that regulates
several functions. Neural regeneration is a complex process that involves matrix secretion …

Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …

The multidrug resistance (MDR) phenotype often accompanies activation of the
phosphatidylinositol 3-kinase (PI3K)/AKT pathway, which renders a survival signal to …

Melanoma is a form of cancer that initiates in melanocytes. Melanoma has multiple
phenotypically distinct subpopulation of cells, some of them have embryonic like plasticity …

Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …

Lung cancer is the second most common and the leading cause of cancer related deaths
globally. Tyrosine Kinase Inhibitors (TKIs) are among the common therapeutic strategies in …

The health and homeostasis of skeletal muscle are preserved by a population of tissue-
resident muscle stem cells (MuSCs) that maintain a state of mitotic and metabolic …

Malignant melanoma is a highly metastatic cancer that bears responsibility for the majority of
skin cancer-related deaths. Amidst the research efforts to better understand melanoma …