Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

ME Bouton, S Maren, GP McNally - Physiological reviews, 2021 - journals.physiology.org
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

Why are women so vulnerable to anxiety, trauma-related and stress-related disorders? The potential role of sex hormones

SH Li, BM Graham - The Lancet Psychiatry, 2017 - thelancet.com
Increased prevalence, severity, and burden of anxiety, trauma-related and stress-related
disorders in women compared with men has been well documented. Evidence from a variety …

Sex differences in anxiety-like behaviors in rats

JL Scholl, A Afzal, LC Fox, MJ Watt, GL Forster - Physiology & behavior, 2019 - Elsevier
The use of animal models for behavioral and pharmaceutical testing is employed in many
different fields of research but often relies solely on male animals. When females are …

Sex differences in fear extinction

ER Velasco, A Florido, MR Milad, R Andero - … & Biobehavioral Reviews, 2019 - Elsevier
Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …

The neurobiological basis of sex differences in learned fear and its inhibition

HLL Day, CW Stevenson - European Journal of Neuroscience, 2020 - Wiley Online Library
Learning that certain cues or environments predict threat enhances survival by promoting
appropriate fear and the resulting defensive responses. Adapting to changing stimulus …

Mechanisms of sex differences in fear and posttraumatic stress disorder

TS Ramikie, KJ Ressler - Biological psychiatry, 2018 - Elsevier
Following sexual maturity, females disproportionately have higher rates of posttraumatic
stress disorder (PTSD) and experience greater symptom severity and chronicity as …

Risk for midlife psychosis in women: critical gaps and opportunities in exploring perimenopause and ovarian hormones as mechanisms of risk

KM Culbert, KN Thakkar, KL Klump - Psychological medicine, 2022 - cambridge.org
Women show a heightened risk for psychosis in midlife that is not observed in men. The
menopausal transition (ie perimenopause) and accompanying changes in ovarian …

Perspectives on fear generalization and its implications for emotional disorders

AM Jasnow, JF Lynch III, TL Gilman… - Journal of …, 2017 - Wiley Online Library
Although generalization to conditioned stimuli is not a new phenomenon, renewed interest
in understanding its biological underpinning has stemmed from its association with a …

Estrogen, progesterone, and the menstrual cycle: A systematic review of fear learning, intrusive memories, and PTSD

NM Garcia, RS Walker, LA Zoellner - Clinical psychology review, 2018 - Elsevier
Women are disproportionately affected by posttraumatic stress disorder (PTSD), and
gonadal hormones are implicated in fear learning processes associated with PTSD. In …

Hormonal cycles, brain network connectivity, and windows of vulnerability to affective disorder

JM Andreano, A Touroutoglou, B Dickerson… - Trends in …, 2018 - cell.com
The rate of affective disorder is substantially higher in women than in men, and considerable
evidence points to the actions of ovarian hormones in mediating this disparity. In this …