Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …

Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful
microbes. They are instrumental in initiating innate and adaptive immune responses against …

Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of inflammation and cell
death. Many sites on RIPK1, including serine 25, are phosphorylated to inhibit its kinase …

Cancer cells take advantage of signaling cascades to meet their requirements for sustained
growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation …

Plant immunity must be tightly controlled to avoid activation of defense mechanisms in the
absence of pathogen attack. Protein phosphorylation is a common mechanism regulating …

Interferon (IFN) regulatory factor 7 (IRF7) plays a key role in the production of IFN‐α in
response to viral infection, and phosphorylation at IRF7 C‐terminal serine sites is prelude to …

Overexpression of immune-related genes is widely reported in myelodysplastic syndromes
(MDSs), and chronic immune stimulation increases the risk for developing MDS. Aberrant …

The cholinergic signaling pathways have been recently implicated in the development of
various human cancers. However, the underlying molecular mechanism remains largely …

Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular
patterns (DAMPs) are recognized by different cellular pathogen recognition receptors …

Protein phosphatase 1γ (PP1γ), a member of mammalian protein phosphatases,
serine/threonine phosphatases, catalyzes the majority of protein dephosphorylation events …