In terms of antinociceptive action, the main mode of action of magnesium involves its
antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central …

Peripheral neuropathy (PN), associated with diabetes, neurotoxic chemotherapy, human
immunodeficiency virus (HIV)/antiretroviral drugs, alcoholism, nutrient deficiencies, heavy …

Microvascular complications are responsible for a major proportion of the burden associated
with diabetes contributing to substantial morbidity, mortality, and healthcare burden in …

BACKGROUND: In a randomized, double-blind, prospective study, we investigated whether
an intraoperative high versus low dose of remifentanil increased postoperative hyperalgesia …

Neuropathic pain is a common diabetic complication affecting 8–16% of diabetic patients. It
is characterized by aberrant symptoms of spontaneous and stimulus‐evoked pain including …

Background Bladder-related pain symptoms in patients with bladder pain
syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory …

Magnesium plays an important role in the prevention of central sensitization and in the
attenuation of established pain hypersensitivity, and its main mode of action appears to …

Magnesium has been shown to produce an antinociceptive effect on animal models of
neuropathic and inflammatory pain. It has also been shown to exert an analgesic effect on …

The aim of this study was to explore the relationship between serum magnesium and
peripheral nerve function in patients with type 2 diabetes (T2DM). A total of 978 T2DM …

Trace elements represent a group of essential metals or metaloids necessary for life, present
in minute amounts. Analgesic adjuvants can enhance the effect of other pain drugs or be …