Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …
[HTML][HTML] The evolving concept of liver cancer stem cells
K Nio, T Yamashita, S Kaneko - Molecular cancer, 2017 - Springer
Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …
chemoresistance. The major malignant phenotypes of cancer, including recurrence …
YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation
C Zhang, S Huang, H Zhuang, S Ruan, Z Zhou… - Oncogene, 2020 - nature.com
Abstract N 6-methyladenosine (m6A) RNA methylation contributes to the cancer stem cell
(CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown …
(CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown …
[PDF][PDF] Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR‐338‐3p/PKM2 axis under hypoxic stress
Q Li, X Pan, D Zhu, Z Deng, R Jiang, X Wang - Hepatology, 2019 - Wiley Online Library
Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …
cancers, demands a higher rate of glycolysis to meet the increasing demands for …
[HTML][HTML] mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs
Z Chen, Q He, T Lu, J Wu, G Shi, L He, H Zong… - Nature …, 2023 - nature.com
Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression
and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in …
and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in …
[HTML][HTML] Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
C Gu, Z Wang, N Zhou, G Li, Y Kou, Y Luo, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N 6-methyladenosine (m 6 A) emerges as one of the most important
modification of RNA. Bladder cancer is a common cancer type in developed countries, and …
modification of RNA. Bladder cancer is a common cancer type in developed countries, and …
[HTML][HTML] LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
P Zhu, Y Wang, J Wu, G Huang, B Liu, B Ye… - Nature …, 2016 - nature.com
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …
[HTML][HTML] Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta …
Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …
[PDF][PDF] A positive feedback loop between cancer stem‐like cells and tumor‐associated neutrophils controls hepatocellular carcinoma progression
SL Zhou, D Yin, ZQ Hu, CB Luo, ZJ Zhou, HY Xin… - …, 2019 - Wiley Online Library
Tumor‐associated neutrophils (TANs) play a crucial role in tumor development and
progression in the cancer microenvironment. Despite increased understanding of TAN …
progression in the cancer microenvironment. Despite increased understanding of TAN …
LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling
Y Wang, P Zhu, J Luo, J Wang, Z Liu, W Wu… - The EMBO …, 2019 - embopress.org
Hepatocellular carcinoma (HCC) is the most prevalent liver cancer, characterized by a high
rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to …
rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to …