Epithelial ovarian cancer experimental models

E Lengyel, JE Burdette, HA Kenny, D Matei, J Pilrose… - Oncogene, 2014 - nature.com
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …

Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application

A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …

The hen as a model of ovarian cancer

PA Johnson, JR Giles - Nature Reviews Cancer, 2013 - nature.com
The domestic laying hen is the only non-human animal that spontaneously develops ovarian
cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen …

Ovarian cancer: applications of chickens to humans

A Barua, JM Bahr - Annual review of animal biosciences, 2022 - annualreviews.org
The lack of preclinical models of spontaneous ovarian cancer (OVCA), a fatal gynecological
malignancy, is a significant barrier to generating information on early changes indicative of …

Genistein prevents development of spontaneous ovarian cancer and inhibits tumor growth in hen model

K Sahin, E Yenice, B Bilir, C Orhan, M Tuzcu… - Cancer Prevention …, 2019 - AACR
Genistein, the major isoflavone in soybean, has been reported to exert anticancer effects on
various types of cancer including ovarian cancer; however, its chemopreventive effects and …

Ovarian cancer immunotherapy: preclinical models and emerging therapeutics

CW McCloskey, GM Rodriguez, KJC Galpin… - Cancers, 2018 - mdpi.com
Immunotherapy has emerged as one of the most promising approaches for ovarian cancer
treatment. The tumor microenvironment (TME) is a key factor to consider when stimulating …

[HTML][HTML] A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population

CW McCloskey, RL Goldberg, LE Carter… - Frontiers in …, 2014 - frontiersin.org
Improving screening and treatment options for patients with epithelial ovarian cancer has
been a major challenge in cancer research. Development of novel diagnostic and …

Neoplastic diseases

V Nair, I Gimeno, J Dunn, G Zavala… - Diseases of …, 2020 - Wiley Online Library
This chapter deals primarily with the three most economically important virus‐induced
transmissible neoplastic diseases of poultry, namely: the herpesvirus‐induced Marek's …

Interacting networks of the hypothalamic–pituitary–ovarian axis regulate layer hens performance

J Zhao, H Pan, Y Liu, Y He, H Shi, C Ge - Genes, 2023 - mdpi.com
Egg production is a vital biological and economic trait for poultry breeding. The
'hypothalamic–pituitary–ovarian (HPO) axis' determines the egg production, which affects …

Characteristics of in vivo model systems for ovarian cancer studies

P Tudrej, KA Kujawa, AJ Cortez, KM Lisowska - Diagnostics, 2019 - mdpi.com
An understanding of the molecular pathogenesis and heterogeneity of ovarian cancer holds
promise for the development of early detection strategies and novel, efficient therapies. In …