Epithelial ovarian cancer experimental models
Epithelial ovarian cancer (OvCa) is associated with high mortality and, as the majority (>
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
75%) of women with OvCa have metastatic disease at the time of diagnosis, rates of survival …
Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application
A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …
conventional chemotherapy and new biological drugs have not been shown to cure the …
The hen as a model of ovarian cancer
PA Johnson, JR Giles - Nature Reviews Cancer, 2013 - nature.com
The domestic laying hen is the only non-human animal that spontaneously develops ovarian
cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen …
cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen …
Ovarian cancer: applications of chickens to humans
A Barua, JM Bahr - Annual review of animal biosciences, 2022 - annualreviews.org
The lack of preclinical models of spontaneous ovarian cancer (OVCA), a fatal gynecological
malignancy, is a significant barrier to generating information on early changes indicative of …
malignancy, is a significant barrier to generating information on early changes indicative of …
Genistein prevents development of spontaneous ovarian cancer and inhibits tumor growth in hen model
Genistein, the major isoflavone in soybean, has been reported to exert anticancer effects on
various types of cancer including ovarian cancer; however, its chemopreventive effects and …
various types of cancer including ovarian cancer; however, its chemopreventive effects and …
Ovarian cancer immunotherapy: preclinical models and emerging therapeutics
CW McCloskey, GM Rodriguez, KJC Galpin… - Cancers, 2018 - mdpi.com
Immunotherapy has emerged as one of the most promising approaches for ovarian cancer
treatment. The tumor microenvironment (TME) is a key factor to consider when stimulating …
treatment. The tumor microenvironment (TME) is a key factor to consider when stimulating …
[HTML][HTML] A new spontaneously transformed syngeneic model of high-grade serous ovarian cancer with a tumor-initiating cell population
CW McCloskey, RL Goldberg, LE Carter… - Frontiers in …, 2014 - frontiersin.org
Improving screening and treatment options for patients with epithelial ovarian cancer has
been a major challenge in cancer research. Development of novel diagnostic and …
been a major challenge in cancer research. Development of novel diagnostic and …
Interacting networks of the hypothalamic–pituitary–ovarian axis regulate layer hens performance
J Zhao, H Pan, Y Liu, Y He, H Shi, C Ge - Genes, 2023 - mdpi.com
Egg production is a vital biological and economic trait for poultry breeding. The
'hypothalamic–pituitary–ovarian (HPO) axis' determines the egg production, which affects …
'hypothalamic–pituitary–ovarian (HPO) axis' determines the egg production, which affects …
Characteristics of in vivo model systems for ovarian cancer studies
An understanding of the molecular pathogenesis and heterogeneity of ovarian cancer holds
promise for the development of early detection strategies and novel, efficient therapies. In …
promise for the development of early detection strategies and novel, efficient therapies. In …