Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target
the μ opioid receptor whose activation results in adverse effects like respiratory depression …

This chapter provides a short overview of the history of morphine since it's isolation by
Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal …

Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …

Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the
treatment of pain, but activation of MOR with current opioid analgesics also produces …

Opioids are widely used in chronic pain management, despite major concerns about their
risk of adverse events, particularly abuse, misuse, and respiratory depression from …

Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an
endogenous ligand for the NOP receptor, ample evidence has revealed unique functional …

The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse
effects, such as respiratory depression and physical dependence, necessitate the …

In our society today, pain has become a main source of strain on most individuals. It is
crucial to develop novel treatments against pain while focusing on decreasing their adverse …

The global “opioid crisis” has placed enormous pressure on the opioid ligand discovery
community to produce novel opioid analgesics with superior opioid-related adverse-effect …

Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied
by significant adverse effects including constipation, tolerance, dependence, and respiratory …