The ability of ubiquitin to form up to eight different polyubiquitin chain linkages generates
complexity within the ubiquitin proteasome system, and accounts for the diverse roles of …

Ubiquitylation is one of the most abundant and versatile post-translational modifications
(PTMs) in cells. Its versatility arises from the ability of ubiquitin to form eight structurally and …

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-
translational modifications controlling intracellular signalling events. However, the ubiquitin …

Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76–
amino acid polypeptide, ubiquitin, is primarily attached to the ϵ-amino group of lysines in …

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein
degradation pathways in mammalian cells: the proteasome, the lysosome, and the …

Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane
cargoes into transport vesicles that fuse with early endosomes. The process is responsive to …

Ubiquitylation is a widely used post-translational protein modification that regulates many
biological processes, including immune responses. The role of ubiquitin in immune …

Efficient genetic modification of herpesviruses such as Kaposi's sarcoma-associated
herpesvirus (KSHV) has come to rely on bacterial artificial chromosome (BAC) technology …

Multivesicular bodies (MVBs) are crucial intermediates in the trafficking of ubiquitinated
receptors and other cargo destined for lysosomes. The formation of MVBs by invagination of …

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the
host with an important surveillance mechanism to protect against invading pathogens …