Cross-presentation designates the presentation of exogenous antigens on major
histocompatibility complex class I molecules and is essential for the initiation of cytotoxic …

Cross-presentation is a critical function of dendritic cells (DCs) required for induction of
antitumor immune responses and success of cancer immunotherapy. It is established that …

Hepatocellular carcinoma (HCC) is a common malignancy. CD8+ T cell-mediated immune
response is critical for the inhibition of HCC progression. M2 macrophages participate in …

Endoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control
mechanism through which misfolded, unassembled and some native proteins are targeted …

Cross-presentation of antigens by dendritic cells (DCs) is critical for initiation of anti-tumor
immune responses. Yet, key steps involved in trafficking of antigens taken up by DCs remain …

Hippo signaling controls the expression of genes regulating cell proliferation and survival
and organ size. The regulation of core components in the Hippo pathway by …

Background Ubiquitination is a basic post-translational modification of intracellular proteins
and can be reversed enzymatically by DUBs (deubiquitinating enzymes). More than 90 …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired
differentiation and uncontrolled proliferation of myeloid blasts. Tumor suppressor p53 is …

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to
retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating …

Age-related alterations of the immune system compromise the host's ability to respond to
pathogens, but how immune aging is regulated is still poorly understood. Here, we identify …