Abstract Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is
found in the cytoplasm and mitochondria of mammalian cells. Like most selenoenzymes, it …

This review addresses the role of the essential trace element, selenium, in type-2 diabetes
mellitus (T2DM) and its metabolic co-morbidities, ie, metabolic syndrome, obesity and non …

Key points Reactive oxygen species (ROS) and nitric oxide (NO) regulate exercise‐induced
nuclear factor erythroid 2‐related factor 2 (NFE2L2) expression in skeletal muscle. NFE2L2 …

It is now accepted that nutrient abundance in the blood, especially glucose, leads to the
generation of reactive oxygen species (ROS), ultimately leading to increased oxidative …

Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

Oxidative stress and antioxidants play an important role in obesity etiopathology. Genetic
variants, including single nucleotide polymorphisms (SNPs) of the antioxidant-related …

Selenium compounds that contain selenol functions or can be metabolized to selenols are
toxic via superoxide and H 2 O 2 generation, when ingested at dosages beyond …

Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its
possible roles in obesity development and in adipocyte metabolism are unclear. The …

Selenium (Se) is a micronutrient that maintains biological functions through the action of Se
containing proteins known as selenoproteins. Due to the known antioxidant effects of Se …