Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer
patients because chemoresistance causes recurrence, cancer dissemination and death …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Apoptosis is a programmed cell death that occurs due to the production of several catabolic
enzymes. During this process, several morphological and biochemical changes occur in …

Because MYC plays a causal role in many human cancers, including those with hypoxic and
nutrient-poor tumor microenvironments, we have determined the metabolic responses of a …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative
glycolysis has long been considered as one of the major metabolic pathways that allows …

Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

Small, rapidly dividing pluripotent stem cells (PSCs) have unique energetic and biosynthetic
demands compared with typically larger, quiescent differentiated cells. Shifts between …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …