Lessons from the host defences of bats, a unique viral reservoir
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …
Novel insights into immune systems of bats
In recent years, viruses similar to those that cause serious disease in humans and other
mammals have been detected in apparently healthy bats. These include filoviruses …
mammals have been detected in apparently healthy bats. These include filoviruses …
The Egyptian rousette genome reveals unexpected features of bat antiviral immunity
SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …
virulence in humans. To identify differences between antiviral mechanisms in humans and …
Going to bat (s) for studies of disease tolerance
A majority of viruses that have caused recent epidemics with high lethality rates in people,
are zoonoses originating from wildlife. Among them are filoviruses (eg, Marburg, Ebola) …
are zoonoses originating from wildlife. Among them are filoviruses (eg, Marburg, Ebola) …
Large‐scale genome sampling reveals unique immunity and metabolic adaptations in bats
DD Moreno Santillán, TM Lama… - Molecular …, 2021 - Wiley Online Library
Abstract Comprising more than 1,400 species, bats possess adaptations unique among
mammals including powered flight, unexpected longevity, and extraordinary immunity. Some …
mammals including powered flight, unexpected longevity, and extraordinary immunity. Some …
Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing
L Li, X Peng, M Batliwala, M Bouvier - Nature Communications, 2023 - nature.com
Studies have suggested that MHC class I (MHC I) molecules fluctuate rapidly between
numerous conformational states and these motions support peptide sampling. To date, MHC …
numerous conformational states and these motions support peptide sampling. To date, MHC …
Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals
P Boudinot, S Mondot, L Jouneau… - Proceedings of the …, 2016 - National Acad Sciences
Whereas major histocompatibility class-1 (MH1) proteins present peptides to T cells
displaying a large T-cell receptor (TR) repertoire, MH1Like proteins, such as CD1D and …
displaying a large T-cell receptor (TR) repertoire, MH1Like proteins, such as CD1D and …
[HTML][HTML] High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress
Y g Ten Chionh, J Cui, J Koh, IH Mendenhall… - Cell Stress and …, 2019 - Elsevier
Bats, unique among mammals with powered flight, have many species with the longest size-
proportionate lifespan of all mammals. Evolutionary adaptations would have been required …
proportionate lifespan of all mammals. Evolutionary adaptations would have been required …
The virome of German bats: Comparing virus discovery approaches
C Kohl, A Brinkmann, A Radonić, PW Dabrowski… - Scientific reports, 2021 - nature.com
Bats are known to be reservoirs of several highly pathogenic viruses. Hence, the interest in
bat virus discovery has been increasing rapidly over the last decade. So far, most studies …
bat virus discovery has been increasing rapidly over the last decade. So far, most studies …
Antigenic variation of SARS‐CoV‐2 in response to immune pressure
D Forni, R Cagliani, C Pontremoli, A Mozzi… - Molecular …, 2021 - Wiley Online Library
Abstract Analysis of the bat viruses most closely related to SARS‐CoV‐2 indicated that the
virus probably required limited adaptation to spread in humans. Nonetheless, since its …
virus probably required limited adaptation to spread in humans. Nonetheless, since its …