Histone deacetylases (HDACs) are a family of 18 members that participate in the epigenetic
regulation of gene expression. In addition to histones, some HDACs also deacetylate …

Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus
aureus is a leading cause of biofilm infections on medical devices, including prosthetic …

Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of
coordinating metabolic and inflammatory programs during infection are poorly defined …

In spite of its essential role in culture media, the precise influence of lactate on early mouse
embryonic development remains elusive. Previous studies have implicated lactate …

Staphylococcus aureus is a leading cause of medical device-associated biofilm infections.
This is influenced by the ability of S. aureus biofilm to evade the host immune response …

Neurosurgeries complicated by infection are associated with prolonged treatment and
significant morbidity. Craniotomy is a common neurosurgical procedure; however, the …

Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses, and
microbial dysbiosis associated with CRS is thought to be a key driver of host inflammation …

Protein acetylation, which is dynamically maintained by histone acetyltransferases (HATs)
and deacetylases (HDACs), might play essential roles in hippocampal exercise physiology …

Nontuberculous mycobacteria (NTM) cause pulmonary disease in individuals without
obvious immunodeficiency. This study was initiated to gain insight into the immunological …

Staphylococcus aureus is subdivided into lineages termed sequence types (STs), infections
of which necessitate the expression of virulence factors and metabolic adaptation to the host …