Sialylated N-glycans play essential roles in the immune system, pathogen recognition and
cancer. This review approaches the sialylation of N-glycans from three perspectives. The …

1280 SCIENCE• VOL. 261• 3SEPTEMBER 1993 current mechanism to drive the net forward
transport of molecules such as cholesterol. Indeed, the original function of the Golgi …

The cell wall of gram-positive bacteria can be thought of as representing a unique cell
compartment, which contains anchored surface proteins that require specific sorting signals …

A biological membrane is conceptualized as a system in which membrane proteins are
naturally matched to the equilibrium thickness of the lipid bilayer. Cholesterol, in addition to …

In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

Transcriptional silencing in Saccharomyces cerevisiae at the HM mating-type loci and
telomeres occurs through the formation of a heterochromatin-like structure. HM silencing is …

Eukaryotes are characterized by endomembranes that are connected by vesicular transport
along secretory and endocytic pathways. The compositional differences between the various …

Electron micrograph is taken from Rambourg and Clermont (1990) with permission. The
trans side is recognizable by maturing (Pg) and mature (g) secretory granules. The …

The single transmembrane domains (TMDs) of the resident glycosylation enzymes of the
Golgi apparatus are involved in preventing these proteins moving beyond the Golgi. It has …

The clustering of proteins and lipids in distinct microdomains is emerging as an important
principle for the spatial patterning of biological membranes. Such domain formation can be …