Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

This Review highlights the processing and integration performed by hindbrain nuclei,
focusing on the inputs received by nucleus tractus solitarius (NTS) neurons. These inputs …

Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however,
brain nuclei and mechanism (s) mediating this effect remain poorly understood. Although …