Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain
development in vitro. Typically, the fate of PSCs is guided into subsequent specification …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

Abstract Development requires coordinated interactions between the epiblast, which
generates the embryo proper; the trophectoderm, which generates the placenta; and the …

Abstract Bromodomain-containing protein 9 (BRD9) is a specific subunit of the non-
canonical SWI/SNF (ncBAF) chromatin-remodeling complex, whose function in human …

Aneuploidy is frequently detected in early human embryos as a major cause of early
pregnancy failure. However, how aneuploidy affects cellular function remains elusive. Here …

A hallmark of primate postimplantation embryogenesis is the specification of extraembryonic
mesoderm (EXM) before gastrulation, in contrast to rodents where this tissue is formed only …

Background Human-induced pluripotent stem cells (hiPSCs) are considered an ideal
resource for regenerative medicine because of their ease of access and infinite expansion …