The structure‐based virtual screening (SBVS) has gained immense importance in early drug
discovery. Herein, we report the SBVS‐driven identification of new cholinesterase inhibitors …

Arginases are bimanganese enzymes involved in many human illnesses, and thus are
targets for disease treatments. The screening of traditional medicinal plants demonstrated …

Parkinson's disease resultant in the degeneration of Dopaminergic neurons and
accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic …

Mitochondrial aldehyde dehydrogenase (ALDH2) is a potential target for the treatment of
substance use disorders such as alcohol addiction. Here, we adopted computational …

Metabolic reprogramming in cancer is considered to be one of the most important hallmarks
to drive proliferation, angiogenesis, and invasion. AMP-activated protein kinase activation is …

The gradual nature of age-related neurodegeneration causes Parkinson's disease (PD) and
impairs movement, memory, intellectual ability, and social interaction. One of the most …

Abstract Inhibiting Arginase 1 (ARG1), a metalloenzyme that hydrolyzes l-arginine in the
urea cycle, has been demonstrated as a promising therapeutic avenue in immuno-oncology …

Abstract Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the detoxification of
reactive aldehydes under oxidative stress. Because an estimated 50% of East Asians carry a …

Three neo-clerodane diterpenoids, including two new tinocordifoliols A (1) and B (2) and
one known tinopanoid R (3), were isolated from the ethyl acetate-soluble fraction of the 70 …

The objective of the present study was to study the effect of increasing Growth Hormone
(GH) on arginase activity in sera of Iraqi acromegaly (ACRO) patients. Certain Vital …