The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The overall lifetime risk of heart failure (HF) is similar between men and women, however,
there are marked sex differences in the landscape of this condition that are both important …

Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …