The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …

Covering: 2013 to 2021 As the characteristic metabolites of Euphorbia plants, Euphorbia
diterpenoids have always been a hot topic in related science communities due to their …

Using synthetic biology, it is now time to expand the biosynthetic repertoire of plants and
microalgae by utilizing the chloroplast to augment the production of desired high-value …

Proteolysis Targeting Chimera (PROTAC) is an emerging approach to selectively degrading
target proteins by utilizing endogenous proteasome 1. Since PROTACs can degrade target …

The roots of the plant Euphorbia ebracteolata Hayata (Yue Xian Da Ji) are commonly used
in traditional Chinese medicine to treat multiple diseases such as chronic liver diseases …

Euphorbia species are important sources of polycyclic and macrocyclic diterpenes, which
have been the focus of natural-product-based drug research due to their relevant biological …

The biorelevant sulfur-containing Euphorbia diterpenes with scarce 5/7/6/3 premyrsinane-
and 5/7/6 myrsinane-type backbones were easily constructed from naturally abundant …

Cembrane diterpenoids (cembranoids), characterized by a 14-membered carbon ring and
wide variety of functional groups, found in marine and terrestrial organisms. Many studies …

An efficient Ir-catalyzed biomimetic method for photoisomerization of cyclopropane in
lathyrane-type Euphorbia diterpenes is reported. Lathyrane diterpenes featuring the trans …

In this study, two tigliane diterpenoids, 12-deoxyphorbol-13-hexadecanoate and 12-
deoxyphorbol-13-acetate (prostratin), were identified from the methanol extract of the roots …