Animal models of obesity and diabetes mellitus

M Kleinert, C Clemmensen, SM Hofmann… - Nature Reviews …, 2018 - nature.com
More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

[HTML][HTML] Lack of exercise is a major cause of chronic diseases

FW Booth, CK Roberts, MJ Laye - Comprehensive physiology, 2012 - ncbi.nlm.nih.gov
Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

[HTML][HTML] Pathogenesis and prevention of hepatic steatosis

F Nassir, RS Rector, GM Hammoud… - Gastroenterology & …, 2015 - ncbi.nlm.nih.gov
Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

High‐intensity intermittent exercise and fat loss

SH Boutcher - Journal of obesity, 2011 - Wiley Online Library
The effect of regular aerobic exercise on body fat is negligible; however, other forms of
exercise may have a greater impact on body composition. For example, emerging research …

The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women

EG Trapp, DJ Chisholm, J Freund… - International journal of …, 2008 - nature.com
Objective: To determine the effects of a 15-week high-intensity intermittent exercise (HIIE)
program on subcutaneous and trunk fat and insulin resistance of young women. Design and …

Neurobiology of exercise

RK Dishman, HR Berthoud, FW Booth, CW Cotman… - …, 2006 - Wiley Online Library
Voluntary physical activity and exercise training can favorably influence brain plasticity by
facilitating neurogenerative, neuroadaptive, and neuroprotective processes. At least some of …

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

T Garland Jr, H Schutz, MA Chappell… - Journal of …, 2011 - journals.biologists.com
Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …

The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward

CM Novak, PR Burghardt, JA Levine - Neuroscience & Biobehavioral …, 2012 - Elsevier
Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …

Central and peripheral regulation of food intake and physical activity: pathways and genes

NR Lenard, HR Berthoud - Obesity, 2008 - Wiley Online Library
A changing environment and lifestyle on the background of evolutionary engraved and
perinatally imprinted physiological response patterns is the foremost explanation for the …

Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats

RS Rector, JP Thyfault, RT Morris… - American Journal …, 2008 - journals.physiology.org
Exercise training is commonly prescribed for treatment of nonalcoholic fatty liver disease
(NAFLD). We sought to determine whether exercise training prevents the development of …