It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

The old Greek aphorism 'Panta Rhei'('everything flows') is true for all living things in general.
As a dynamic process, calcium signaling plays fundamental roles in cellular activities under …

BACKGROUND AND PURPOSE Several studies have demonstrated anti‐proliferative and
pro‐apoptotic actions of cannabinoids on various tumours, together with their anti …

As a nutritionally essential metal ion, zinc (Zn) not only constitutes a structural element for
more than 3000 proteins but also plays important regulatory functions in cellular signal …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …

Members of the Orai family are highly selective calcium ion channels that play an important
role in store-operated calcium entry. Among the three known Orai isoforms, Orai3 has …

5-Fluorouracil (5-Fu) is commonly used in the chemotherapy of colorectal cancer (CRC), but
resistance to 5-Fu occurs in most cases, allowing cancer progression. Suppressing ABCB1 …