Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the synthesis of
monounsaturated fatty acids, mainly oleate (18: 1) and palmitoleate (16: 1). These represent …

Geneticists have repeatedly turned to population isolates for mapping and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …

Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes
Down syndrome, the most frequent genetic cause of significant mental retardation, which …

Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is
required for the biosynthesis of oleate (18: 1) and palmitoleate (16: 1). These …

Many" complex" human diseases, which involve multiple genetic and environmental
determinants, have increased in incidence during the past 2 decades. During the same time …

Stearoyl-CoA desaturase (SCD)(EC 1.14. 99.5) is an endoplasmic reticulum-bound enzyme
that catalyzes the Δ9-cis desaturation of saturated fatty acyl-CoAs, the preferred substrates …

In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …

Traditional risk factors for coronary artery disease (CAD) predict about 50% of the risk of
developing CAD. The Adult Treatment Panel (ATP) III has defined emerging risk factors for …

Down syndrome (DS) is one of the more commonly occurring genetic disorders, where
mental retardation is combined with nutritional diseases. It is caused by having a third copy …

Background—Conventional wisdom suggests that a diagnosis of familial combined
hyperlipidemia (FCHL) carries a substantially greater risk of premature coronary artery …