Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by
facilitating tumor cell invasion and dissemination to distant organs. Recent evidences …

The development of precision medicine for the management of metastatic breast cancer is
an appealing concept; however, major scientific and logistical challenges hinder its …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …

Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning
numerous biological processes, has lately made its mark as a much sought-after therapeutic …

The IGF1R signaling pathway is a complex and tightly regulated network that is critical for
cell proliferation, growth, and survival. IGF1R is a potential therapeutic target for patients …

Type I insulin-like growth factor receptor (IGF-1R) has long been recognized for its role in
tumorigenesis and growth, but only recently have the tools for targeting the IGF pathway …

PURPOSE Monoclonal antibodies directed against insulin-like growth factor-1 receptor (IGF-
1R) have shown activity in patients with relapsed Ewing sarcoma. The primary objective of …

BACKGROUND Insulin‐like growth factor‐1 receptor (IGF‐1R) is implicated in the
pathogenesis of rhabdomyosarcoma (RMS), osteosarcoma (OS), and synovial sarcoma …

Numerous epidemiological and pre-clinical studies have demonstrated that the
insulin/insulin-like growth factor (IGF) system plays a key role in the development and …