Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …

This review discusses the relationship between cellular senescence and radiation exposure.
Given the wide range of ionizing radiation sources encountered by people in professional …

Brain metastases develop in over 60% of advanced melanoma patients and negatively
impact quality of life and prognosis. In a murine melanoma model, we previously showed …

Macrophages are essential immune cells for host defense against bacterial pathogens after
radiation injury. However, the role of macrophage phagocytosis in infection following …

Background Traditional concepts of radiobiology model the direct radiation-induced cellular
cytotoxicity but are not focused on late and sustained effects of radiation. Recent …

The space environment presents unique stressors, such as microgravity and space
radiation, which can induce molecular and physiological changes in living organisms. To …

Mitochondrial transcription factor A (TFAM) regulates mitochondrial biogenesis, and it is a
candidate target for sensitizing tumor during therapy. Previous studies identified that …

Peroxynitrite is a reactive nitrogen species produced in the intravascular compartment from
superoxide anion and nitric oxide. Peroxynitrite destroys blood plasma proteins and …

Macrophages are abundant immune cells in the tumor microenvironment and are crucial in
regulating tumor malignancy. We previously reported that ionizing radiation (IR) increases …

Long-term exposures to low-dose radiation (LDR) may trigger several specific biological
responses, including dysregulation of the immune and inflammatory systems. Here, we …