Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in
the (extreme) overweight population. Obesity has a great impact on key organs that play a …

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

Skin and soft-tissue infections (SSTIs) are among the most common bacterial infections,
posing considerable diagnostic and therapeutic challenges. Fourteen members of the Italian …

Highlights•Bronchoalveolar lavage for determining epithelial lining fluid exposures of
antibiotics.•Discussion about conducting intrapulmonary pharmacokinetic studies in critically …

The lengthy treatment time for tuberculosis (TB) is a primary cause for the emergence of
multidrug resistant tuberculosis (MDR-TB). One approach to improve TB therapy is to …

The objective of the current review was to provide an updated and comprehensive summary
on pharmacokinetic data describing the distribution of antimicrobials into interstitial fluid …

The pharmacokinetic/pharmacodynamic (PK/PD) indices useful for predicting antimicrobial
clinical efficacy are well established. The most common indices include the time free drug …

Despite the accepted knowledge that the activity of antibiotics depends on the unbound
concentration at the site of infection, current pharmacodynamic analysis mostly relies on …

Pneumonia is a form of lung infection that may be caused by various micro-organisms. The
predominant site of infection in pneumonia is debatable. Advances in the fields of diagnostic …