The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Model organisms are of great importance to our understanding of basic biology and to
making advances in biomedical research. However, the influence of laboratory cultivation on …

Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …

Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

The Hawaiian strain (CB4856) of Caenorhabditis elegans is one of the most divergent from
the canonical laboratory strain N2 and has been widely used in developmental, population …

The genetic variants underlying complex traits are often elusive even in powerful model
organisms such as Caenorhabditis elegans with controlled genetic backgrounds and …

The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …

Recent work on behavioural variation within and between species has furthered our
understanding of the genetic architecture of behavioural traits, the identities of relevant …

The ability to avoid noxious extremes of hot and cold is critical for survival and depends on
thermal nociception. The TRPV subset of transient receptor potential (TRP) channels is heat …

Gene expression becomes more variable with age, and it is widely assumed that this is due
to a decrease in expression regulation. But currently there is no understanding how gene …