Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis

IP Trougakos, E Terpos, H Alexopoulos… - Trends in Molecular …, 2022 - cell.com
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Differential interactions between human ACE2 and spike RBD of SARS-CoV-2 variants of concern

S Kim, Y Liu, Z Lei, J Dicker, Y Cao… - Journal of chemical …, 2021 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. It is known that the receptor …

SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

R Chang, A Mamun, A Dominic, NT Le - Frontiers in physiology, 2021 - frontiersin.org
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

The relationship between pediatric gut microbiota and SARS-CoV-2 infection

L Romani, F Del Chierico, G Macari, S Pane… - Frontiers in cellular …, 2022 - frontiersin.org
This is the first study on gut microbiota (GM) in children affected by coronavirus disease
2019 (COVID-19). Stool samples from 88 patients with suspected severe acute respiratory …

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Heterogeneity of lipopolysaccharide as source of variability in bioassays and LPS-binding proteins as remedy

AC Fux, C Casonato Melo, S Michelini… - International Journal of …, 2023 - mdpi.com
Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …

Alterations in the respiratory tract microbiome in COVID-19: current observations and potential significance

C Merenstein, FD Bushman, RG Collman - Microbiome, 2022 - Springer
SARS-CoV-2 infection causes COVID-19 disease, which can result in consequences
ranging from undetectable to fatal, focusing attention on the modulators of outcomes. The …