Why all the fuss about oxidative phosphorylation (OXPHOS)?
Y Xu, D Xue, A Bankhead III… - Journal of medicinal …, 2020 - ACS Publications
Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive.
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …
[HTML][HTML] An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond
TM Iverson, PK Singh, G Cecchini - Journal of Biological Chemistry, 2023 - ASBMB
Mitochondrial complex II is traditionally studied for its participation in two key respiratory
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
Mitochondrial protein interactions and complexes facilitate mitochondrial function. These
complexes range from simple dimers to the respirasome supercomplex consisting of …
complexes range from simple dimers to the respirasome supercomplex consisting of …
Novel pyrazole-4-acetohydrazide derivatives potentially targeting fungal succinate dehydrogenase: design, synthesis, three-dimensional quantitative structure–activity …
X Wang, M Wang, L Han, F Jin, J Jiao… - Journal of Agricultural …, 2021 - ACS Publications
Succinate dehydrogenase inhibitors (SDHIs) have emerged in fungicide markets as one of
the fastest-growing categories that are widely applied in agricultural production for crop …
the fastest-growing categories that are widely applied in agricultural production for crop …
[HTML][HTML] Insecticidal activity of essential oils from American native plants against Aedes aegypti (Diptera: Culicidae): an introduction to their possible mechanism of …
Searching for new bioactive molecules to design insecticides is a complex process since
pesticides should be highly selective, active against the vector, and bio-safe for humans …
pesticides should be highly selective, active against the vector, and bio-safe for humans …
[HTML][HTML] Mode of action of fluopyram in plant-parasitic nematodes
ASS Schleker, M Rist, C Matera, A Damijonaitis… - Scientific Reports, 2022 - nature.com
Plant-parasitic nematodes (PPN) are responsible for severe yield losses in crop production.
Management is challenging as effective and safe means are rare. Recently, it has been …
Management is challenging as effective and safe means are rare. Recently, it has been …
Discovery of a fungicide candidate targeting succinate dehydrogenase via computational substitution optimization
H Li, YX Wang, XL Zhu, GF Yang - Journal of Agricultural and …, 2021 - ACS Publications
Succinate dehydrogenase (SDH, EC 1.3. 5.1) has proven to be an important fungicidal
target, and the inhibition of SDH is useful in the treatment of plant pathogens. The discovery …
target, and the inhibition of SDH is useful in the treatment of plant pathogens. The discovery …
Expanding the chemical space of succinate dehydrogenase inhibitors via the carbon–silicon switch strategy
G Wei, MW Huang, WJ Wang, Y Wu… - Journal of Agricultural …, 2021 - ACS Publications
The carbon–silicon switch strategy has become a key technique for structural optimization of
drugs to widen the chemical space, increase drug activity against targeted proteins, and …
drugs to widen the chemical space, increase drug activity against targeted proteins, and …
Discovery of N-Methoxy-(biphenyl-ethyl)-pyrazole-carboxamides as Novel Succinate Dehydrogenase Inhibitors
YH Huang, G Wei, Z Liu, Q Lu, JJ Jiang… - Journal of Agricultural …, 2022 - ACS Publications
Succinate dehydrogenase (SDH) inhibitor is one of the research hotspots for the
development of fungicides. Herein, we describe the design and synthesis of N-methoxy …
development of fungicides. Herein, we describe the design and synthesis of N-methoxy …
Discovery of benzothiazolylpyrazole-4-carboxamides as potent succinate dehydrogenase inhibitors through active fragment exchange and link approach
YM Yin, ZY Sun, DW Wang, Z Xi - Journal of Agricultural and Food …, 2023 - ACS Publications
Succinate dehydrogenase (SDH) is an attractive target for developing green fungicides to
manage agricultural pathogens in modern agriculture research. Herein, in this work, we …
manage agricultural pathogens in modern agriculture research. Herein, in this work, we …