Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive.
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …

Mitochondrial complex II is traditionally studied for its participation in two key respiratory
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …

Mitochondrial protein interactions and complexes facilitate mitochondrial function. These
complexes range from simple dimers to the respirasome supercomplex consisting of …

Succinate dehydrogenase inhibitors (SDHIs) have emerged in fungicide markets as one of
the fastest-growing categories that are widely applied in agricultural production for crop …

Searching for new bioactive molecules to design insecticides is a complex process since
pesticides should be highly selective, active against the vector, and bio-safe for humans …

Plant-parasitic nematodes (PPN) are responsible for severe yield losses in crop production.
Management is challenging as effective and safe means are rare. Recently, it has been …

Succinate dehydrogenase (SDH, EC 1.3. 5.1) has proven to be an important fungicidal
target, and the inhibition of SDH is useful in the treatment of plant pathogens. The discovery …

The carbon–silicon switch strategy has become a key technique for structural optimization of
drugs to widen the chemical space, increase drug activity against targeted proteins, and …

Succinate dehydrogenase (SDH) inhibitor is one of the research hotspots for the
development of fungicides. Herein, we describe the design and synthesis of N-methoxy …

Succinate dehydrogenase (SDH) is an attractive target for developing green fungicides to
manage agricultural pathogens in modern agriculture research. Herein, in this work, we …