Medial and orbital frontal cortex in decision-making and flexible behavior

MC Klein-Flügge, A Bongioanni, MFS Rushworth - Neuron, 2022 - cell.com
The medial frontal cortex and adjacent orbitofrontal cortex have been the focus of
investigations of decision-making, behavioral flexibility, and social behavior. We review …

Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans

SN Yaakub, TA White, J Roberts, E Martin… - Nature …, 2023 - nature.com
Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive
technique for focally modulating human brain function. The mechanisms and neurochemical …

The role of the lateral orbitofrontal cortex in creating cognitive maps

KM Costa, R Scholz, K Lloyd, P Moreno-Castilla… - Nature …, 2023 - nature.com
We use mental models of the world—cognitive maps—to guide behavior. The lateral
orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps …

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound

Y Yang, J Yuan, RL Field, D Ye, Z Hu, K Xu, L Xu… - Nature …, 2023 - nature.com
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic
rate and body temperature to survive harsh environmental conditions. Here, we report the …

Imagining the future self through thought experiments

K Miyamoto, MFS Rushworth, N Shea - Trends in Cognitive Sciences, 2023 - cell.com
The ability of the mind to conceptualize what is not present is essential. It allows us to reason
counterfactually about what might have happened had events unfolded differently or had …

Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioral adaptations

BA Wang, M Veismann, A Banerjee, B Pleger - Nature Communications, 2023 - nature.com
The ability to respond flexibly to an ever-changing environment relies on the orbitofrontal
cortex (OFC). However, how the OFC associates sensory information with predicted …

Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex

LR Trambaiolli, X Peng, JF Lehman, G Linn, BE Russ… - Elife, 2022 - elifesciences.org
Three large-scale networks are considered essential to cognitive flexibility: the ventral and
dorsal attention (VANet and DANet) and salience (SNet) networks. The ventrolateral …

General mechanisms of task engagement in the primate frontal cortex

J Grohn, N Khalighinejad, CI Jahn… - Nature …, 2024 - nature.com
Staying engaged is necessary to maintain goal-directed behaviors. Despite this,
engagement exhibits continuous, intrinsic fluctuations. Even in experimental settings …

Neural responses in macaque prefrontal cortex are linked to strategic exploration

CI Jahn, J Grohn, S Cuell, A Emberton, S Bouret… - PLoS …, 2023 - journals.plos.org
Humans have been shown to strategically explore. They can identify situations in which
gathering information about distant and uncertain options is beneficial for the future …

Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates

T Hirabayashi, Y Nagai, Y Hori, Y Hori, K Oyama… - Nature …, 2024 - nature.com
Visual object memory is a fundamental element of various cognitive abilities, and the
underlying neural mechanisms have been extensively examined especially in the anterior …