Despite decades of research aimed at identifying the causes of postpartum depression
(PPD), PPD remains common, and the causes are poorly understood. Many have attributed …

This review highlights recent evidence from clinical and basic science studies supporting a
role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen …

We have been studying the role and mechanism of estrogen action in the survival and
differentiation of neurons in the basal forebrain and its targets in the cerebral cortex …

In this article, we examine evidence supporting the role of reproductive steroids in the
regulation of mood and behavior in women and the nature of that role. In the first half of the …

Pharmacological and biochemical approaches were used to elucidate the involvement of
growth factor signaling pathways mediating estrogen neuroprotection in primary cortical …

Recent evidence indicates that 17 (3-estradiol may have neuroprotective and
neuroregenerative properties. Estradiol is formed locally in neural tissue from precursor …

We have shown that estrogen elicits a selective enhancement of the growth and
differentiation of axons and dendrites (neurites) in the developing CNS. We subsequently …

During development, estrogen has a variety of effects on morphological and
electrophysiological properties of hippocampal neurons. Brain-derived neurotrophic factor …

A growing body of literature describes the effects of estrogen and other gonadal steroids on
the central nervous system. The ability of estrogen to modulate serotonergic function, in …

Estrogen elicits a selective enhancement of the growth and differentiation of axons and
dendrites (neurites) in the developing brain. Widespread colocalization of estrogen and …