Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases

DC Wallace - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
Two major inconsistencies exist in the current neo-Darwinian evolutionary theory that
random chromosomal mutations acted on by natural selection generate new species. First …

[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations

AR Martin, CR Gignoux, RK Walters, GL Wojcik… - The American Journal of …, 2017 - cell.com
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …

[HTML][HTML] The genetic ancestry of african americans, latinos, and european Americans across the United States

K Bryc, EY Durand, JM Macpherson, D Reich… - The American Journal of …, 2015 - cell.com
Over the past 500 years, North America has been the site of ongoing mixing of Native
Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave …

[HTML][HTML] Genetic consequences of the transatlantic slave trade in the Americas

SJ Micheletti, K Bryc, SGA Esselmann… - The American Journal of …, 2020 - cell.com
According to historical records of transatlantic slavery, traders forcibly deported an estimated
12.5 million people from ports along the Atlantic coastline of Africa between the 16th and …

Genotyping, sequencing and analysis of 140,000 adults from Mexico City

A Ziyatdinov, J Torres, J Alegre-Díaz, J Backman… - Nature, 2023 - nature.com
Abstract The Mexico City Prospective Study is a prospective cohort of more than 150,000
adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in …

The genetic structure and history of Africans and African Americans

SA Tishkoff, FA Reed, FR Friedlaender, C Ehret… - science, 2009 - science.org
Africa is the source of all modern humans, but characterization of genetic variation and of
relationships among populations across the continent has been enigmatic. We studied 121 …

Human genetic admixture through the lens of population genomics

S Gopalan, SP Smith, K Korunes… - … of the Royal …, 2022 - royalsocietypublishing.org
Over the past 50 years, geneticists have made great strides in understanding how our
species' evolutionary history gave rise to current patterns of human genetic diversity …

Genome-wide patterns of population structure and admixture in West Africans and African Americans

K Bryc, A Auton, MR Nelson… - Proceedings of the …, 2010 - National Acad Sciences
Quantifying patterns of population structure in Africans and African Americans illuminates
the history of human populations and is critical for undertaking medical genomic studies on …

Genome-wide patterns of population structure and admixture among Hispanic/Latino populations

K Bryc, C Velez, T Karafet… - Proceedings of the …, 2010 - National Acad Sciences
Hispanic/Latino populations possess a complex genetic structure that reflects recent
admixture among and potentially ancient substructure within Native American, European …

Genomic reconstruction of the history of extant populations of India reveals five distinct ancestral components and a complex structure

A Basu, N Sarkar-Roy… - Proceedings of the …, 2016 - National Acad Sciences
India, occupying the center stage of Paleolithic and Neolithic migrations, has been
underrepresented in genome-wide studies of variation. Systematic analysis of genome-wide …