Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy

M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Arbidol as a broad-spectrum antiviral: an update

J Blaising, SJ Polyak, EI Pécheur - Antiviral research, 2014 - Elsevier
Arbidol (ARB) is a Russian-made small indole-derivative molecule, licensed in Russia and
China for prophylaxis and treatment of influenza and other respiratory viral infections. It also …

Recent developments in tubulin polymerization inhibitors: an overview

R Kaur, G Kaur, RK Gill, R Soni, J Bariwal - European journal of medicinal …, 2014 - Elsevier
Microtubules are protein biopolymers formed through polymerization of heterodimers of α-
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …

Visible-light-induced metal and reagent-free oxidative coupling of sp 2 C–H bonds with organo-dichalcogenides: Synthesis of 3-organochalcogenyl indoles

V Rathore, S Kumar - Green Chemistry, 2019 - pubs.rsc.org
Here, a unique visible-light-induced method for the organochalcogenation of the sp2 C–H
bonds of indoles and aniline has been presented using diaryl dichalcogenides (S, Se, and …

Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

Y Jia, X Wen, Y Gong, X Wang - European Journal of Medicinal Chemistry, 2020 - Elsevier
Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to
anticancer agents represents one of the major obstacles for the effective cancer treatment …

A Solvent- and Metal-Free Synthesis of 3-Chacogenyl-indoles Employing DMSO/I2 as an Eco-friendly Catalytic Oxidation System

JB Azeredo, M Godoi, GM Martins… - The Journal of …, 2014 - ACS Publications
Herein, we describe a solvent-and metal-free method for the synthesis of 3-chalcogenyl-
indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO …

3-(3, 4, 5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation

Z Wen, J Xu, Z Wang, H Qi, Q Xu, Z Bai, Q Zhang… - European Journal of …, 2015 - Elsevier
Abstract A series of 3-(3, 4, 5-trimethoxyphenylselenyl)-1H-indoles and their selenoxides
were designed as a new class of combretastatin A-4 (CA-4) analogs. The B ring and the cis …

Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents

Y Hong, YY Zhu, Q He, SX Gu - Bioorganic & medicinal chemistry, 2022 - Elsevier
The α-and β-tubulins are the major polypeptide components of microtubules (MTs), which
are attractive targets for anticancer drug development. Indole derivatives display a variety of …

TFA-promoted direct C–H sulfenylation at the C2 position of non-protected indoles

T Hostier, V Ferey, G Ricci, DG Pardo… - Chemical …, 2015 - pubs.rsc.org
A simple, efficient and practical metal-free C–H sulfenylation process at the C2 position of
non-protected indoles has been developed. 2-Thioindoles were obtained in moderate to …

Design, synthesis, and evaluation of orally available clioquinol-moracin M hybrids as multitarget-directed ligands for cognitive improvement in a rat model of …

Z Wang, Y Wang, B Wang, W Li… - Journal of Medicinal …, 2015 - ACS Publications
A novel series of clioquinol-moracin hybrids were designed and synthesized by fusing the
pharmacophores of clioquinol and moracin M, and their activities as multitarget-directed …