Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data

V Ruzsányi, MP Kalapos - Journal of Breath Research, 2023 - iopscience.iop.org
Owing to its connection to cancer metabolism, lactate is a compound that has been a focus
of interest in field of cancer biochemistry for more than a century. Exhaled breath volatile …

Water‐Based Conductive Ink Formulations for Enzyme‐Based Wearable Biosensors

A Tricase, A Imbriano, M Valentino… - Advanced Sensor …, 2024 - Wiley Online Library
Herein, this work reports the first example of second‐generation wearable biosensor arrays
based on a printed electrode technology involving a water‐based graphite ink, for the …

Resolving enantiomers of 2-hydroxy acids by nuclear magnetic resonance

P Lin, DR Crooks, WM Linehan, TWM Fan… - Analytical …, 2022 - ACS Publications
Biologically important 2-hydroxy carboxylates such as lactate, malate, and 2-
hydroxyglutarate exist in two enantiomeric forms that cannot be distinguished under achiral …

Mechanism of action of lactic acid on histones in cancer

R Sgarra, S Battista, L Cerchia… - Antioxidants & redox …, 2024 - liebertpub.com
Significance: Metabolic end products and intermediates can exert signaling functions as
chemical sources for histone posttranslational modifications, which remodel chromatin and …

StereoPHIP: Stereoselective Parahydrogen‐Induced Polarization

MT Huynh, E Buchanan, S Chirayil… - Angewandte Chemie …, 2023 - Wiley Online Library
Parahydrogen‐induced polarization (PHIP) followed by polarization transfer to 13C is a
rapidly developing technique for the generation of 13C‐hyperpolarized substrates. Chirality …

[HTML][HTML] Intervention on lactate in cancer: A promising approach for the development of cancer therapeutics

D Sharma, M Singh, R Gupta, V Kumar, V Kumar… - Advances in Cancer …, 2022 - Elsevier
Lactate, the main product of tumor glycolysis is considered one of the most crucial
metabolites in the tumor microenvironment. The reprogrammed cancer cell metabolism is …

Fluorescence enantioselective sensing of lactic acid enantiomers by Zn-MOC@ CQDs with double chiral building blocks

X Jia, M Lu, W Zhang, W Zhao, A Yu, S Zhang - Microchemical Journal, 2024 - Elsevier
Chiral carbon quantum dots (CQDs) with–SH,–NH 2 functional groups were grafted onto a
metal–organic cage (Zn-MOC) with unsaturated metal sites through coordination bond, and …

[HTML][HTML] Challenges of Spatially Resolved Metabolism in Cancer Research

AN Lane, RM Higashi, TWM Fan - Metabolites, 2024 - mdpi.com
Stable isotope-resolved metabolomics comprises a critical set of technologies that can be
applied to a wide variety of systems, from isolated cells to whole organisms, to define …

Atrioventricular re-entrant tachycardia and atrioventricular node re-entrant tachycardia in a patient with cancer under chemotherapy: a case report and literature review

M Dai, Y Chen, J Qin - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Cardio-oncology is a new field of interest in cardiology focusing on the detection and
treatment of cardiovascular diseases, such as arrhythmias, myocarditis, and heart failure, as …