EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

P Stenroos, I Guillemain, F Tesler, O Montigon… - Elife, 2024 - elifesciences.org
In patients suffering absence epilepsy, recurring seizures can significantly decrease their
quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized …

Prediction of therapeutic intensity level from automatic multiclass segmentation of traumatic brain injury lesions on CT-scans

C Brossard, J Grèze, JA de Busschère, A Attyé… - Scientific Reports, 2023 - nature.com
The prediction of the therapeutic intensity level (TIL) for severe traumatic brain injury (TBI)
patients at the early phase of intensive care unit (ICU) remains challenging. Computed …

FUS-mediated BBB opening leads to transient perfusion decrease and inflammation without acute or chronic brain lesion

S Rigollet, C Rome, T Ador, E Dumont, C Pichon… - …, 2024 - pmc.ncbi.nlm.nih.gov
Impact: The permeabilization of the BBB to deliver therapeutics with MR-guided FUS
redefines therapeutic strategies as it improves patient outcomes. To ensure the best …

Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

LP Munting, M Derieppe, E Suidgeest, L Hirschler… - Elife, 2021 - elifesciences.org
Impaired cerebrovascular function is an early biomarker for cerebral amyloid angiopathy
(CAA), a neurovascular disease characterized by amyloid-β accumulation in the cerebral …

Bayesian inverse regression for vascular magnetic resonance fingerprinting

F Boux, F Forbes, J Arbel, B Lemasson… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Standard parameter estimation from vascular magnetic resonance fingerprinting (MRF) data
is based on matching the MRF signals to their best counterparts in a grid of coupled …

Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy

F Boux, F Forbes, N Collomb, E Zub, L Mazière… - …, 2021 - Wiley Online Library
Objective Improving the identification of the epileptogenic zone and associated seizure‐
spreading regions represents a significant challenge. Innovative brain‐imaging modalities …

How absence seizures impair sensory perception: Insights from awake FMRI and simulation studies in rats

P Stenroos, I Guillemain, F Tesler, O Montigon… - bioRxiv, 2023 - biorxiv.org
Absence seizures are characterized by regular and generalized spike-and-wave electrical
patterns in the brain, resulting in unresponsiveness to environmental stimuli. In patients …

[HTML][HTML] In vivo biocompatibility assessment of 3D printed bioresorbable polymers for brain tissue regeneration. A feasibility study

J Clauzel, N Colitti, M Combeau, W Labriji, L Robert… - Regenerative …, 2024 - Elsevier
Introduction The limited capacity of brain tissue to regenerate after acute injury, hampered
by cell death, edema and inflammation, has led to an interest in promising and innovative …

Evidence of cerebral hypoperfusion consecutive to ultrasound‐mediated blood‐brain barrier opening in rats

W Labriji, J Clauzel, JL Mestas… - Magnetic …, 2023 - Wiley Online Library
Purpose This work aims to explore the effect of Blood Brain Barrier (BBB) opening using
ultrasound combined with microbubbles injection on cerebral blood flow in rats. Methods …

[HTML][HTML] Microbeam Radiation Therapy Opens a Several Days' Vessel Permeability Window for Small Molecules in Brain Tumor Vessels

M Potez, C Rome, B Lemasson, P Heemeryck… - International Journal of …, 2024 - Elsevier
Purpose Synchrotron microbeam radiation therapy (MRT), based on an inhomogeneous
geometric and microscopic irradiation pattern of the tissues with high dose and high dose …