Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

The full neutrophil heterogeneity and differentiation landscape remains incompletely
characterized. Here, we profiled> 25,000 differentiating and mature mouse neutrophils using …

The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to
antigens and commensals, and a tissue susceptible to one of the most prevalent human …

Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …

Neutrophils are the most abundant innate immune cells in the circulation and they are the
first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein …

Neutrophils provide a critical line of defense in immune responses to various pathogens,
inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work …

Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection
where they direct a broad armamentarium of antimicrobial products against pathogens …

The use of transcriptomes as reliable proxies for cellular proteomes is controversial. In the
small intestine, enterocytes operate for 4 days as they migrate along villi, which are highly …

Neutrophils are important effector cells in the host defense against invading
microorganisms. One of the mechanisms they use to eliminate pathogens is the release of …