Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

After liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver
injury, hepatocyte proliferation is impaired—a feature of human chronic liver disease,. It is …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …

Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …

Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Chronic diseases confer tissue and organ damage that reduce quality of life and are largely
refractory to therapy. Although stem cells hold promise for treating degenerative diseases …