Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …

Chronic pain is highly prevalent and burdensome, affecting millions of people worldwide.
Although it emerges at any point in life, it often manifests in adolescence. Given that …

During neocortical development, tight regulation of neurogenesis-to-astrogenesis switching
of neural precursor cells (NPCs) is critical to generate a balanced number of each neural …

Oligodendroglial cells are the myelinating cells of the central nervous system. While
myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and …

Leukodystrophies are a class of rare heterogeneous disorders which affect the white matter
of the brain, ultimately leading to a disruption in brain development and a damaging effect …

Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation of
distinct functional regions including the neocortex and ganglionic eminence. While Bone …

Recent studies have demonstrated that epigenetic modifications are deeply involved in
neurogenesis; however, the precise mechanisms remain largely unknown. To determine the …

During brain development, neural precursor cells (NPCs) in different brain regions produce
different types of neurons, and each of these regions plays a different role in the adult brain …

Epigenetic mechanisms play an important regulatory role in neural processes associated
with brain development and phenotypic outcome, and do so from early embryonic …

The brain is the most complex organ in mammals and understanding the origin of this
complexity is a major challenge for developmental biologists. Crucial to the size and …