Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Serotoninergic neurons in the central nervous system impinge on many other neurons and
modulate their neurotransmitter release. This review focuses on 1) the function of …

The 5-hydroxytryptamine type-3 (5-HT3) receptor is a cation-selective ion channel of the Cys-
loop superfamily. 5-HT3 receptor activation in the central and peripheral nervous systems …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to
dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the …

Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …

Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …

In patients with treatment‐resistant epilepsy (TRE), cannabidiol (CBD) produces variable
improvement in seizure control. Patients in the University of Alabama at Birmingham CBD …