Role of microbiota-gut-brain axis in regulating dopaminergic signaling

S Hamamah, A Aghazarian, A Nazaryan, A Hajnal… - Biomedicines, 2022 - mdpi.com
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally in
vital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and …

Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments

JE Barrett, A Shekarabi, S Inan - Pharmacological Reviews, 2023 - ASPET
Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

V Chuong, M Farokhnia, S Khom, CL Pince, SK Elvig… - JCI insight, 2023 - ncbi.nlm.nih.gov
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …

Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats

C Aranäs, CE Edvardsson, OT Shevchouk, Q Zhang… - …, 2023 - thelancet.com
Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

[HTML][HTML] Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial

MK Klausen, ME Jensen, M Møller, N Le Dous… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Alcohol use disorder (AUD) is a chronic, relapsing brain disorder that accounts
for 5% of deaths annually, and there is an urgent need to develop new targets for …

Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study

W Wang, ND Volkow, NA Berger, PB Davis… - Molecular …, 2024 - nature.com
Cannabis is the most frequently used illicit drug in the United States with more than 45
million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high …

GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders

L Leggio, CS Hendershot, M Farokhnia… - Nature Medicine, 2023 - nature.com
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use
disorders | Nature Medicine Skip to main content Thank you for visiting nature.com. You are …

[HTML][HTML] Social, clinical, and policy implications of ultra-processed food addiction

AN Gearhardt, NB Bueno, AG DiFeliceantonio… - bmj, 2023 - bmj.com
Social, clinical, and policy implications of ultra-processed food addiction | The BMJ Skip to main
content Intended for healthcare professionals Access provided by Google Indexer Subscribe …

Therapeutic strategies of small molecules in the microbiota–gut–brain axis for alcohol use disorder

L Xie, W Rungratanawanich, Q Yang, G Tong, E Fu… - Drug Discovery …, 2023 - Elsevier
The microbiota–gut–brain axis (MGBA) is important in maintaining the structure and function
of the central nervous system (CNS) and is regulated by the CNS environment and signals …

Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic …

B Cruz, V Vozella, V Borgonetti, R Bullard… - Molecular …, 2024 - nature.com
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …