Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Regulation of intracellular deoxynucleoside triphosphate (dNTP) pool is critical to genomic
stability and cancer development. Imbalanced dNTP pools can lead to enhanced …

Interferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-
stimulated genes (ISGs). The activity of known ISGs is insufficient to account for the …

Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif
and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide …

SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of
deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and …

CD32 has been shown to be preferentially expressed in latently HIV-1-infected cells in an in
vitro model of quiescent CD4 T cells. Here we show that stimulation of CD4+ T cells with IL …

Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …

The deoxynucleoside triphosphate triphosphohydrolase and 3′→ 5′ exonuclease
SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 …

Objective: The eradication of HIV necessitates elimination of the HIV latent reservoir.
Identifying host determinants governing latency and reservoir size in the setting of …

The host intrinsic innate immune system drives antiviral defenses and viral restriction, which
includes the production of soluble factors, such as type I and III interferon (IFN), and …