Inflammaging is characterized by the upregulation of the inflammatory response that occurs
with advancing age; its roots are strongly embedded in evolutionary theory. Inflammaging is …

The systemic stress response triggered by surgical trauma is characterised by sterile
inflammation preceding metabolic and neuroendocrine dysregulation. However, the …

Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …

Context: Activation of the hypothalamic-pituitary-adrenal (HPA) axis represents one of
several important responses to stressful events and critical illnesses. Despite a large volume …

Objective Review the main aspects of the definition, diagnosis, and management of pediatric
patients with sepsis and septic shock. Source of data A search was carried out in the …

Typical for critical illnesses are substantial alterations within the hypothalamic–anterior
pituitary–peripheral hormonal axes that are proportionate to the risk of poor outcome. These …

Rationale: High cortisol levels are of prognostic value in sepsis. The predictive value of
cortisol in pneumonia is unknown. Routinely available assays measure serum total cortisol …

Critical illness is characterized by striking alterations in the hypothalamic–anterior-pituitary–
peripheral-hormone axes, the severity of which is associated with a high risk of morbidity …

There is increasing interest in the hormone melatonin in postoperative and critically ill
patients. The roles of melatonin in the regulation of the sleep-wake cycle, resetting of …

Objectives The aim of the present analyses was to examine the association between
cortisol, DHEA sulphate (DHEAS) and the cortisol: DHEAS ratio and mortality. Design This …