Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …

Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …

Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …

Neurons have extensive processes and communication between those processes and the
cell body is crucial to neuronal function and survival. Thus, neurons are uniquely dependent …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …

Cytoplasmic dynein is a multisubunit microtubule motor complex that, together with its
activator, dynactin, drives vesicular cargo toward the minus ends of microtubules. Huntingtin …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that
causes selective death of motor neurons followed by paralysis and death. A subset of ALS …

Recent studies have shown that the transport of microtubules (MTs) and neurofilaments
(NFs) within the axon is rapid, infrequent, asynchronous, and bidirectional. Here, we used …