Abstract In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious
promise to generate mutations in virtually every protein-coding gene of the mouse genome …

The mouse has long been an important model for the study of human genetic disease.
Through the application of genetic engineering and mutagenesis techniques, the number of …

Gene targeting in embryonic stem cells has become the principal technology for
manipulation of the mouse genome, offering unrivalled accuracy in allele design and access …

A number of large-scale efforts are underway to define the relationships between genes and
proteins in various species. But, few attempts have been made to systematically classify all …

The laboratory mouse is widely considered the model organism of choice for studying the
diseases of humans, with whom they share 99% of their genes. A distinguished history of …

Neurobehavioural analysis of mouse phenotypes requires the monitoring of mouse
behaviour over long periods of time. In this study, we describe a trainable computer vision …

Abstract The Mammalian Phenotype (MP) Ontology enables robust annotation of
mammalian phenotypes in the context of mutations, quantitative trait loci and strains that are …

The activation and accumulation of lung fibroblasts resulting in aberrant deposition of
extracellular matrix components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis …

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ
significantly among individuals and are difficult to model with genetically engineered lines of …

The study of inherited monogenic diseases has contributed greatly to our mechanistic
understanding of pathogenic mutations and gene regulation, and to the development of …