Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …

S Khan, H Ullah, R Hussain, Y Khan, MU Khan… - Journal of Molecular …, 2023 - Elsevier
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …

[HTML][HTML] Bis-indole based triazine derivatives: Synthesis, characterization, in vitro β-glucuronidase anti-cancer and anti-bacterial evaluation along with in silico …

S Khan, W Rehman, F Rahim, R Hussain… - Arabian Journal of …, 2023 - Elsevier
The present work described the synthetic procedure adopted for the synthesis of bis-indole-
based triazine derivatives via a series of reactions. All the compounds were synthesized …

Hybrid molecules of thiadiazole-based benzothioate and benzenesulfonothioate: synthesis, structural analysis, and evaluation as potential inhibitors of thymidine …

Y Khan, S Khan, W Rehman, R Hussain… - Journal of Molecular …, 2023 - Elsevier
The thiadiazole-based benzothioate (3a-f) and benzenesulfonothioate (5a-f) hybrid
derivatives were designed and synthesized in a single step reaction. All the synthesized …

Advancing drug discovery: Thiadiazole derivatives as multifaceted agents in medicinal chemistry and pharmacology

BA Babalola, L Sharma, O Olowokere, M Malik… - Bioorganic & Medicinal …, 2024 - Elsevier
In this dispensation of rapid scientific and technological advancements, significant efforts are
being made to curb health-related diseases. Research discoveries have highlighted the …

Synthesis, biological and molecular modelling for 1, 3, 4-thiadiazole sulfonyl thioureas: bacterial and fungal activity

ND Thanh, VN Toan, NTK Giang, HTK Van… - RSC Medicinal …, 2023 - pubs.rsc.org
Some substituted thioureas (6a–i) containing a 1, 3, 4-thiadiazole ring were synthesized by
the reaction of the corresponding substituted 2-amino-1, 3, 4-thiadiazoles 3a–i with p …

Coupling of NIR spectroscopy and chemometrics for the quantification of dexamethasone in pharmaceutical formulations

A Biancolillo, C Scappaticci, M Foschi, C Rossini… - Pharmaceuticals, 2023 - mdpi.com
Counterfeit or substandard drugs are pharmaceutical formulations in which the active
pharmaceutical ingredients (APIs) have been replaced or ingredients do not comply with the …

Polymer-Degrading Enzymes of Pseudomonas chloroaphis PA23 Display Broad Substrate Preferences

N Mohanan, MCH Wong, N Budisa… - International Journal of …, 2023 - mdpi.com
Although many bacterial lipases and PHA depolymerases have been identified, cloned, and
characterized, there is very little information on the potential application of lipases and PHA …

In Situ Synthesis of a Tumor-Microenvironment-Responsive Chemotherapy Drug

X Wang, A Oyane, T Inose, M Nakamura - Pharmaceutics, 2023 - mdpi.com
Current chemotherapy still suffers from unsatisfactory therapeutic efficacy, multi-drug
resistance, and severe adverse effects, thus necessitating the development of techniques to …

Atherosclerotic-derived endothelial cell response conducted by titanium oxide nanotubes

E Beltrán-Partida, B Valdez-Salas… - Materials, 2023 - mdpi.com
Atherosclerosis lesions are described as the formation of an occlusive wall-vessel plaque
that can exacerbate infarctions, strokes, and even death. Furthermore, atherosclerosis …

Cooperativity of ESPT and aggregation-induced emission effects—an experimental and theoretical analysis of a 1, 3, 4-thiadiazole derivative

I Budziak-Wieczorek, D Kaczmarczyk, K Rząd… - International Journal of …, 2024 - mdpi.com
4-[5-(Naphthalen-1-ylmethyl)-1, 3, 4-thiadiazol-2-yl] benzene-1, 3-diol (NTBD) was
extensively studied through stationary UV–vis absorption and fluorescence measurements …